Hyperbaric oxygen causes both antiinflammation and antipyresis in rabbits.
MED Â Â 09-26 Â Â 200919374861 NDN- 230-0960-7463-1
AUTHORS- Niu, Ko-Chi; Huang, Wu-Tein; Lin, Mao-Tsun; Huang, Kuo-Fong
JOURNAL NAME- Eur J Pharmacol
VOLUME 606
NUMBER 1-3
PUBLICATION DATE- 2009 Mar 15
PP 240-5
DOCUMENT TYPE- Journal Article; Research Support, Non-U.S. Gov’t
JOURNAL CODE- 1254354
JOURNAL SUBSET- MEDJSIM
ISSN- 1879-0712
CORPORATE AUTHOR- Department of Biotechnology, Southern Taiwan University, Tainan, Taiwan.
PUBLICATION COUNTRY- Netherlands
LANGUAGE- English
Current study was attempted to assess whether hyperbaric oxygen pretreatment or treatment exerts its antipyresis by reducing circulating interleukin-6 and hypothalamic glutamate, hydroxyl radicals and prostaglandin-E(2) in rabbits. It was found that systemic administration of lipopolysaccharide induced increased levels of both core temperature and hypothalamic levels of glutamate, hydroxyl radicals, and prostaglandin E(2) accompanied by increased plasma levels of interleukin-6. The rise in both the core temperature and hypothalamic glutamate, hydroxyl radicals and prostaglandin-E(2) could also be induced by intracerebroventricular injection of interleukin-6. Pretreatment or treatment with hyperbaric oxygen significantly reduced the lipopolysaccharide-induced overproduction of circulating interleukin-6, and hypothalamic glutamate, prostaglandin E(2), and hydroxyl radicals. The febrile response caused by central administration of interleukin-6 could also be suppressed by hyperbaric oxygen pretreatment or treatment. Simultaneous administration of an anti-oxidant (e.g., N-acetyl-L-cysteine) significantly enhanced the antipyretic effects exerted by hyperbaric oxygen treatment. These results indicate that hyperbaric oxygen pretreatment or treatment may exert its antipyresis by inhibiting the glutamate-hydroxyl radicals-prostaglandin-E(2) pathways in the hypothalamus and circulating interleukin-6 accumulation during lipopolysaccharide-fever.
Hyperbaric oxygen preconditioning activates ribosomal protein S6 kinases and reduces brain swelling after intracerebral hemorrhage.
MED Â Â 09-26 Â Â 200819388337Â Â NDN- 230-0961-6545-4
AUTHORS- Qin, Z; Hua, Y; Liu, W; Silbergleit, R; He, Y; Keep, R F; Hoff, J T; Xi, G
JOURNAL NAME- Acta Neurochir Suppl
VOLUME 102
PUBLICATION DATE- 2008
PP 317-20
DOCUMENT TYPE- Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov’t
JOURNAL CODE- 100962752
JOURNAL SUBSET- MEDJSIM
ISSN- 0065-1419
CORPORATE AUTHOR- Department of Neurosurgery, Room 5018, BSRB, University of Michigan, Ann Arbor, MI 48109-2200, USA.
CONTRACT OR GRANT NUMBER- NS-017760.NS.NINDS NIH HHS; NS-039866.NS.NINDS NIH HHS; NS-047245.NS.NINDS NIH HHS
PUBLICATION COUNTRY- United States; United States; United States; Austria
LANGUAGE- English
BACKGROUND: New protein synthesis is key to ischemic tolerance induced by preconditioning and ribosomal protein S6 kinases (p70 S6 K) are important enzymes in protein synthesis. Hyperbaric oxygen preconditioning (HBOP) reduces ischemic brain damage. This study investigated if HBOP can activate p70 S6 K and increase new protein synthesis and if HBOP induces brain tolerance against brain swelling after intracerebral hemorrhage (ICH).
METHODS: There were two parts of the studies. 1) Rats received five consecutive sessions of HBOP. Twenty-four hours after HBOP, the rats had an ICH and were sacrificed one or three days later for brain edema measurement. 2) Rats received five sessions of HBOP or control pretreatment and were sacrificed for Western blot analysis and immunohistochemistry of activated p70 S6 K and heme oxygenase-1 (HO-1).
FINDINGS: Five sessions of HBOP significantly reduced brain edema in the ipsilateral basal ganglia after ICH. Western blot analysis showed that HBOP activated p70 S6 K and increased HO-1 levels in the basal ganglia. Strong activated p70 S6 K immunoreactivity was also found in the basal ganglia.
CONCLUSIONS: Our results suggest activation of p70 S6 K may have a role in heat shock protein synthesis after HBOP and may contribute to HBOP-induced brain protection.
Hyperbaric oxygen therapy for consciousness disturbance following head injury in subacute phase.
MED Â Â 09-26 Â Â 200819388281Â Â NDN- 230-0961-6489-5
AUTHORS- Nakamura, Takehiro; Kuroda, Yasuhiro; Yamashita, Susumu; Kawakita, Kenya; Kawai, Nobuyuki; Tamiya, Takashi; Itano, Toshifumi; Nagao, Seigo
JOURNAL NAME- Acta Neurochir Suppl
VOLUME 102
PUBLICATION DATE- 2008
PP 21-4
DOCUMENT TYPE- Journal Article
JOURNAL CODE- 100962752
JOURNAL SUBSET- MEDJSIM
ISSN- 0065-1419
CORPORATE AUTHOR- Department of Neurobiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0173, Japan. tanakamu@kms.ac.jp
PUBLICATION COUNTRY- Austria
LANGUAGE- English
BACKGROUND: Hyperbaric oxygen (HBO) therapy has been shown to improve outcome after brain injury, however its mechanisms are not understood. The purpose of the present study was to investigate the effect of hyperbaric oxygen (HBO) therapy on the cerebral circulation and metabolism of patients with disturbances in consciousness after head injury in the subacute phase.
METHODS: Seven head injury patients underwent HBO treatment after leaving the intensive care unit. Oxygen (100% O2, 2.7 atm absolute) was delivered to patients in a hyperbaric chamber for 60 min every 24 h (total five treatments/patient). Cerebral circulation monitoring (mean flow velocity: mFV, and pulsatility index: PI at horizontal portion of middle cerebral artery by transcranial Doppler) and cerebral metabolism monitoring (arterio-jugular venous difference of oxygen: AJDO2 and jugular venous lactate: lac-JV) before and after the series of treatments were evaluated.
FINDINGS: Both PI and lac-JV were significantly decreased after HBO theatment, while there were no significant changes in mFV and AJDO2. The decreased PI and lac-JV after HBO therapy might indicate that this treatment couples cerebral circulation and metabolism.
CONCLUSIONS: The measurement of cerebral circulation and metabolism parameters, especially PI and lac-JV, is useful for estimation of effect of HBO therapy in patients with distubances in consciousness after head injury in the subacute phase.
Loss of protein kinase Cgamma in knockout mice and increased retinal sensitivity to hyperbaric oxygen
MED Â Â 09-25 Â Â 200919365031Â Â NDN- 230-0958-0343-6
AUTHORS- Yevseyenkov, Vladimir V; Das, Satyabrata; Lin, Dingbo; Willard, Lloyd; Davidson, Harriet; Sitaramayya, Ari; Giblin, Frank J; Dang, L; Takemoto, Dolores J
JOURNAL NAME- Arch Ophthalmol
VOLUME 127
NUMBER 4
PUBLICATION DATE- 2009 Apr
PP 500-6
DOCUMENT TYPE- Journal Article; Research Support, N.I.H., Extramural
JOURNAL CODE- 7706534
JOURNAL SUBSET- MEDJSAIM; MEDJSIM
ISSN- 1538-3601
CORPORATE AUTHOR- Department of Biochemistry, 141 Chalmers Hall, Kansas State University, Manhattan, Kansas 66506, USA.
CONTRACT OR GRANT NUMBER- EY07158.EY.NEI NIH HHS; R01-13421.PHS HHS; R24 EY02027.EY.NEI NIH HHS; R24 EY04803.EY.NEI NIH HHS
PUBLICATION COUNTRY- United States; United States; United States; United States; United States
LANGUAGE- English
OBJECTIVE: To determine if loss of protein kinase Cgamma (PKCgamma) results in increased structural damage to the retina by hyperbaric oxygen (HBO), a treatment used for several ocular disorders.
METHODS: Six-week-old mice were exposed in vivo to 100% HBO 3 times a week for 8 weeks. Eyes were dissected, fixed, embedded in Epon, sectioned, stained with toluidine blue O, and examined by light microscopy.
RESULTS: The thicknesses of the inner nuclear and ganglion cell layers were increased. Destruction of the outer plexiform layer was observed in the retinas of the PKCgamma-knockout mice relative to control mice. Exposure to HBO caused significant degradation of the retina in knockout mice compared with control mice. Damage to the outer segments of the photoreceptor layer and ganglion cell layer was apparent in central retinas of HBO-treated knockout mice.
CONCLUSIONS: Protein kinase Cgamma-knockout mice had increased retinal sensitivity to HBO. Results demonstrate that PKCgamma protects retinas from HBO damage. CLINICAL RELEVANCE: Care should be taken in treating patients with HBO, particularly if they have a genetic disease, such as spinocerebellar ataxia type 14, a condition in which the PKCgamma is mutated and nonfunctional.
Mortality in necrotizing fasciitis.
MED Â Â 09-26 Â Â 200819385468Â Â NDN- 230-0961-2764-5
AUTHORS- Rajput, Akram; Waseem; Samad, Abdul; Khanzada, Tariq Wahab; Shaikh, Gul Muhammad; Channa, Ghulam Asghar
JOURNAL NAME- J Ayub Med Coll Abbottabad
VOLUME 20
NUMBER 2
PUBLICATION DATE- 2008 Apr-Jun
PP 96-8
DOCUMENT TYPE- Journal Article
JOURNAL CODE- 8910750
JOURNAL SUBSET- MEDJSIM
ISSN- 1025-9589
CORPORATE AUTHOR- Department of Surgery, Isra University, Hyderabad. akramrajput2006@yahoo.com
PUBLICATION COUNTRY- Pakistan
LANGUAGE- English
OBJECTIVE: The objective of this study was to determine the mortality rate in patients presenting with Necrotizing Fasciitis. This prospective study was conducted at ward 26, JPMC Karachi over a period of two years from March 2001 to Feb 2003.
METHODS: All patients above the age of 12 years diagnosed to be having Necrotizing Fasciitis and admitted through the Accident and emergency department were included in this study. After resuscitation, the patients underwent the emergency exploration and aggressive surgical debridement. Post-operatively, the patients were managed in isolated section of the ward. The patients requiring grafting were referred to plastic surgery unit. The patients were followed up in outpatients department for about two years.
RESULTS: Over all, 25 male and 5 female patients fulfilled the inclusion criteria and were included in this study. The common clinical manifestations include redness, swelling, discharging abscess, pain, fever, skin necrosis and foul smelling discharge etc. The most common predisposing factor was Diabetes mellitus whereas the most commonly involved site was perineum. All patients underwent aggressive and extensive surgical debridements. The common additional procedures included Skin grafting, Secondary suturing, Cystostomy and Orchidectomy. Bacteroides and E. coli were the main micro-organisms isolated in this study. Bacteroides was the most common microorganism isolated among the eight patients who died.
CONCLUSION: Necrotizing Fasciitis is a potentially life threatening emergency condition and carries the mortality rate of about 26.6%. The major contributing factors to increase the mortality missed initially diagnosed, old age, diabetes mellitus truncal involvement and late presentation. Anorectal involvement of disease carry worse prognosis. Hyperbaric oxygen therapy and proper use of unprocessed honey reduced the mortality rate.
Necrotizing fasciitis following transobturator tape treated by extensive surgery and hyperbaric oxygen
MED Â Â 09-26 Â Â 200918509584Â Â NDN- 230-0960-0530-4
AUTHORS- Flam, Folke; Boijsen, Magnus; Lind, Folke
JOURNAL NAME- Int Urogynecol J Pelvic Floor Dysfunct
VOLUME 20
NUMBER 1
PUBLICATION DATE- 2009 Jan
PP 113-5
DOCUMENT TYPE- Journal Article
JOURNAL CODE- 9514583
JOURNAL SUBSET- MEDJSIM
ISSN- 1433-3023
CORPORATE AUTHOR- Department of Gynecology, Capio S:t Goeran Hospital, S-112 81 Stockholm, Sweden. folke.flam@gynekologkliniken.se
PUBLICATION COUNTRY- England
LANGUAGE- English
The transobturator sling procedure (TVT-O) was developed to minimize surgical risks involved in treating genuine stress incontinence. All data suggest that most risks associated with the retropubic route such as injuries to the bladder, intestines or vessels are practically obsolete with the obturator route. However, severe soft-tissue infections have been reported with this new technique. In this case report, necrotizing fasciitis (NF) developed shortly after a TVT-O procedure. This life-threatening complication required extensive debridements, a diverting colostomy, antibiotics, and eight sessions of hyperbaric oxygen (HBO) therapy. We emphasize the importance of a unified interdisciplinary clinical approach in severe NF with rapid progression and systemic toxemia. Primary, aggressive but tissue-saving debridements together with antibiotics are the cornerstones of therapy. HBO therapy can oxygenate infected hypoxic tissues to help marginally viable tissues survive, reduce the inflammatory response, improve leukocyte bacterial oxidative killing capacity, and achieve infection control and healing.
Protective effect of hyperbaric oxygen therapy on experimental brain contusions.
MED Â Â 09-26 Â Â 200819388363Â Â NDN- 230-0961-6571-0
AUTHORS- Voigt, Cornelia; Foerschler, Annette; Jaeger, Matthias; Meixensberger, Jourgen; Kouppers-Tiedt, Lea; Schuhmann, Martin U
JOURNAL NAME- Acta Neurochir Suppl
VOLUME 102
PUBLICATION DATE- 2008
PP 441-5
DOCUMENT TYPE- Journal Article
JOURNAL CODE- 100962752
JOURNAL SUBSET- MEDJSIM
ISSN- 0065-1419
CORPORATE AUTHOR- Department of Neurosurgery, University of Leipzig, 04103 Leipzig, Germany. dat, conny@web.de
PUBLICATION COUNTRY- Austria
LANGUAGE- English
BACKGROUND: We evaluated the effect of hyperbaric oxygen therapy (HBO) on experimental brain contusions in rats using magnetic resonance imaging (MRI).
MATERIALS AND METHODS: Ten Sprague-Dawley rats were investigated at 24 h and 72 h after controlled cortical impact injury. One hour after trauma, 5 rats were treated for 60 min with 100% oxygen at 2.5 absolute atmosphere (ATA), 5 were kept at normobaric room air. MRI was performed longitudinally at 24 h and 72 h after injury. Lesion volume was determined in T2 weighted MRI scans. Relative apparent diffusion coefficient (ADC) changes were calculated in comparison to the contralateral side.
RESULTS: Following HBO, T2 lesion volume was smaller at 24 h versus controls (63.1 +/- 16.5 mm3 vs. 87.4 +/- 13.8 mm3, p < 0.05), and decreased further at 72 h (46.8 +/- 17.8 mm3 vs. 92.5 +/- 13.1 mm3, p < 0.01). At 24 h, the mean relative ADC change in the lesion area decreased from + 26.8 +/- 2.3% in controls to + 2.3 +/- 12.2% in HBO animals (p < 0.01). At 72 h, the HBO effect on relative ADC values was less when compared to 24 h.
DISCUSSION: A 60-minute exposure to hyperbaric oxygen starting 1 h after impact injury significantly attenuated lesion growth and relative increase of ADC values within the contused area for up to 72 h. Thus, a “single-shot” HBO treatment seems to have long-lasting neuroprotective effects on the contused brain and its penumbra.
Pulmonary Barotrauma in Divers During Emergency Free Ascent Training: Review of 124 Cases
BIO Â Â 12-20 Â Â PREV200900270187Â Â NDN- 244-0594-8340-8
AUTHORS- Lafere, Pierre; Germonpre, Peter; Balestra, Costantino
JOURNAL NAME- Aviation Space and Environmental Medicine
VOLUME 80
NUMBER 4
PUBLICATION DATE- APR 2009
PP 371-375
RELEASE YEAR OR PUBLICATION YEAR- 2009
DOCUMENT TYPE- Article
ISSN- 0095-6562
ADDRESS- Mil Hosp Queen Astrid, Ctr Hyperbar Oxygen Therapy, Bruynst 1, B-1020 Brussels, Belgium
EMAIL- doc.lafere@skynet.be
DOCUMENT URL OR DOI- 10.3357/ASEM.2402.2009
LANGUAGE- English
Introduction: Experience from treating diving accidents indicates that a large proportion of divers suffering from pulmonary barotraumas (PBT) or arterial gas embolism (AGE) were engaged in training dives, specifically emergency free ascent (EFA). We tried to verify this relationship and to calculate, if possible, the risk associated with normal recreational dives, training dives, and EFA training dives.
Methods: All diving accidents treated at the Centre for Hyperbaric Oxygen Therapy (Brussels, Belgium) from January 1995 until October 2005 were reviewed, Data on the average lumber of dives performed and the proportion of in-water skills training dives were obtained from the major Belgian dive associations.
Results: A total of 124 divers were treated, of whom 34 (27.4%) were diagnosed with PBT. Of those, 20 divers (58.8%) had symptoms of AGE. In 16 of those, EFA training exercise was deemed responsible for the injury. The association between EFA training and PBT proved to be very significant, with an odds ratio of 11.33 (95%, confidence interval: 2.186 to 58.758). it was possible to calculate that a training dive (0.456 to 1.36/10,000) carries a 100 to 400 times higher risk, and an ascent training dive (1.82 to 5.46/10,000 dives) a 500 to 1500 times higher risk for PBT than a non-training dive (0.0041 to 0.0043/10,000 dives).
Discussion: This Study confirms a significant association between El-A training dives and the occurrence of PBT.
Tension pneumocephalus: a rare complication after hyperbaric oxygen therapy.
MED Â Â 09-25 Â Â 200919371560Â Â NDN- 230-0959-3709-3
AUTHORS- Lee, Ching-Hsing; Chen, Wei-Chun; Wu, Chao-I; Hsia, Te-Chun
JOURNAL NAME- Am J Emerg Med
VOLUME 27
NUMBER 2
PUBLICATION DATE- 2009 Feb
PP 257.e1-3
DOCUMENT TYPE- Journal Article
JOURNAL CODE- 8309942
JOURNAL SUBSET- MEDJSIM
ISSN- 1532-8171
CORPORATE AUTHOR- Department of Emergency Medicine, Chang Gung Memorial Hospital, Taipei, Chang Gung University College of Medicine, Taoyuan, Taiwan, ROC.
PUBLICATION COUNTRY- United States
LANGUAGE- English
The study aimed to describe a patient with multiple skull bone fractures and a cerebrospinal fluid (CSF) leak who received hyperbaric oxygen therapy (HBOT). A 40-year-old man presented with subdural hemorrhage, skull bone fractures, facial bone fractures, sinus fractures, and CSF leakage after a one-story fall. He received HBOT as an adjunctive treatment to reduce brain edema and increase oxygen availability in brain tissue. Tension pneumocephalus developed after HBOT. Bur hole drainage was performed emergently to relieve the tension pneumocephalus. Cranioplasty and repair of skull base fracture were subsequently performed. The patient was discharged in a vegetative state. We proposed a possible mechanism by which tension pneumocephalus developed after HBOT sessions in this patient. Pneumocephalus, untreated skull base fracture, and CSF leakage should be considered contraindications to HBOT.
Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws.
MED Â Â 09-26 Â Â 200919371820Â Â NDN- 230-0961-1774-5
AUTHORS- Freiberger, John J
JOURNAL NAME- J Oral Maxillofac Surg
VOLUME 67
NUMBER 5 Suppl
PUBLICATION DATE- 2009 May
PP 96-106
DOCUMENT TYPE- Journal Article; Research Support, Non-U.S. Gov’t
JOURNAL CODE- 8206428
JOURNAL SUBSET- MEDJSAIM; MEDJSD; MEDJSIM
ISSN- 1531-5053
CORPORATE AUTHOR- Center for Hyperbaric Medicine and Environmental Physiology, Duke University Medical Center, Durham, NC 27710, USA. freib002@mc.duke.edu
PUBLICATION COUNTRY- United States
LANGUAGE- English
Bisphosphonates suppress bone turnover by disrupting osteoclast signal transduction, maturation, and longevity. In some patients, it has been hypothesized that suppressed turnover can impair oral wound healing, leading to a distressing, osteopetrosis-like jaw necrosis called bisphosphonate-related osteonecrosis of the jaws (BRONJ). Hyperbaric oxygen (HBO), as an adjunct to surgery and antibiotics, might have utility in the treatment of BRONJ because it produces reactive oxygen and nitrogen species that positively modulate the redox-sensitive intracellular signaling molecules involved in bone turnover. The efficacy of HBO in the treatment of BRONJ is currently under investigation in randomized controlled trials at Duke University and the University of Minnesota, and the early results have been encouraging. This report discusses osteoclast biology, how HBO has the potential to augment bone turnover by way of the signaling effects on osteoclasts, the available clinical data on HBO in the treatment of BRONJ, the ongoing randomized controlled trials of HBO, and the study-associated efforts to find biomarkers to characterize an individual’s risk of developing this disease.